2-Nitrophenol → 2-Nitroanisole

HRID 273938

반응식

HRID 273938 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[OH:10])([O-:3])=[O:2].[CH3:11]CCCCCCCC.CNC(=NC)C1C=CC=CC=1.C(=O)(OC)OC>CO>[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[O:10][CH3:11])([O-:3])=[O:2]

참가 물질

6

반응물 4

HCID 69472-NitrophenolHCID 8141NonaneHCID 12021Dimethyl CarbonateHCID 185669Benzenecarboximidamide, n,n'-dimethyl-

생성물 1

HCID 70482-Nitroanisole

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

10 mol of 2-nitrophenol was charged into a stirred, heated reactor, along with 800 ml of nonane and 5% N,N'-dimethylbenzoamidine, and the mixture was heated to 150° C. Then 12 mol of dimethyl carbonate was added portionwise over 5 hr. The methanol produced by the reaction was removed by distillation over a distillation column. After completion of the reaction, the reaction mixture was refined by distillation. 2-Nitroanisole was obtained in the amount of about 9 mol, corresponding to a yield of c. 90%, based on the starting amount of 2-nitrophenol.

후처리

  1. temperatureheated reactor
  2. customwas removed by distillation over a distillation column
  3. customAfter completion of the reaction
  4. distillationthe reaction mixture was refined by distillation

출처 및 근거

ORD 기록
ord-323d01ddebbe403da32e604664b98523
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05387718

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