Sodium borohydride → (2-Trimethylsilyl-4-furyl)methanol

HRID 273967노트

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HRID 273967 반응식
[CH3:1][Si:2]([CH3:11])([CH3:10])[C:3]1[O:4][CH:5]=[C:6]([CH:8]=[O:9])[CH:7]=1.[BH4-].[Na+]>CO>[OH:9][CH2:8][C:6]1[CH:7]=[C:3]([Si:2]([CH3:11])([CH3:10])[CH3:1])[O:4][CH:5]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 156632515-(Trimethylsilyl)furan-3-carbaldehyde

생성물 1

HCID 13333558(2-Trimethylsilyl-4-furyl)methanol

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2-Trimethylsilyl-4-furaldehyde (1.57 g, 9.35 mmol) was added to a suspension of sodium borohydride (424 mg, 11.2 mmol) in methanol (10 ml) at 0° C. After 45 minutes, most of the methanol was evaporated and the residue taken up in ethyl ether. The ethyl ether extracts were combined, washed (water), dried (magnesium sulfate) and evaporated to dryness to give an oil, which was purified by flash chromatography on silica using 30% ethyl ether/hexane to give the title alcohol as a pale yellow oil.

후처리

  1. custommost of the methanol was evaporated
  2. washwashed (water)
  3. dry with materialdried (magnesium sulfate)
  4. customevaporated to dryness
  5. customto give an oil, which
  6. customwas purified by flash chromatography on silica using 30% ethyl ether/hexane

출처 및 근거

ORD 기록
ord-0381c8e967c94b669ec2927800657379
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05387606

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