(RS)-Salsolinol → alpha-(3,4-Dimethoxyphenyl)-3,4-dihydro-6,7-dihydroxy-1-methyl-alpha-[(4-methylphenyl)thio]-2(1H)-isoquinoline-pentanenitrile

HRID 273980

반응식

HRID 273980 반응식
Cl[CH2:2][CH2:3][CH2:4][C:5]([S:18][C:19]1[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][CH:20]=1)([C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([O:16][CH3:17])[CH:9]=1)[C:6]#[N:7].[CH3:26][CH:27]1[C:36]2[C:31](=[CH:32][C:33]([OH:38])=[C:34]([OH:37])[CH:35]=2)[CH2:30][CH2:29][NH:28]1>>[CH3:17][O:16][C:10]1[CH:9]=[C:8]([C:5]([S:18][C:19]2[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][CH:20]=2)([CH2:4][CH2:3][CH2:2][N:28]2[CH2:29][CH2:30][C:31]3[C:36](=[CH:35][C:34]([OH:37])=[C:33]([OH:38])[CH:32]=3)[CH:27]2[CH3:26])[C:6]#[N:7])[CH:13]=[CH:12][C:11]=1[O:14][CH3:15]

참가 물질

3

반응물 2

HCID 54456(RS)-SalsolinolHCID 10738259alpha-(3-Chloropropyl)-3,4-dimethoxy-alpha-[(4-methylphenyl)-thio]benzeneacetonitrile

생성물 1

HCID 10839653alpha-(3,4-Dimethoxyphenyl)-3,4-dihydro-6,7-dihydroxy-1-methyl-alpha-[(4-methylphenyl)thio]-2(1H)-isoquinoline-pentanenitrile수율 18,336.6%

실험 절차

The procedure of Example 3 is repeated using 1.0 g of α-(3-chloropropyl)-3,4-dimethoxy-α-[(4-methylphenyl)thio]benzeneacetonitrile and 0.76 g of 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline. This affords 0,253 g of the desired product as a beige gum.

출처 및 근거

ORD 기록
ord-8521c75ae97f43b082438604cb2efbcb
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05387685

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