Potassium thiocyanate → HCID 10655699, 화합물

HRID 274286노트

반응식

HRID 274286 반응식
Cl[CH2:2][CH2:3][C:4]([CH3:11])([CH3:10])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[S-:12][C:13]#[N:14].[K+]>CN(C)C=O.O>[CH3:10][C:4]([CH3:11])([CH2:3][CH2:2][S:12][C:13]#[N:14])[C:5]([O:7][CH2:8][CH3:9])=[O:6]

참가 물질

5

반응물 2

HCID 516872Potassium thiocyanateHCID 10797430Ethyl 4-chloro-2,2-dimethylbutanoate

생성물 1

HCID 10655699HCID 10655699, 화합물수율 65.9%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

반응 조건

온도
100 °C

실험 절차

In 100 ml of dimethylformamide were dissolved 22.1 g of ethyl 4-chloro-2,2-dimethylbutyrate and 14.5 g of potassium thiocyanate and the solution was stirred at 100° C. for 7 hours. The reaction mixture was poured in 500 ml of water and extracted with ethyl ether. The extract was washed with water and dried (MgSO4) and the solvent was distilled off. The residue was subjected to vacuum distillation to provide 16.4 g of the title compound as colorless oil. b.p. 109°-111° C./0.3 mmHg

후처리

  1. extractionextracted with ethyl ether
  2. washThe extract was washed with water
  3. dry with materialdried (MgSO4)
  4. distillationthe solvent was distilled off
  5. distillationThe residue was subjected to vacuum distillation

출처 및 근거

ORD 기록
ord-523cc06023b34faaad3d5774d551a396
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05389633

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