Thioacetamide → 5-(2-Methyl-4-thiazolyl)-3-nitropyrocatechol hydrobromide

HRID 274467

반응식

HRID 274467 반응식
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8]([OH:14])=[C:7]([OH:15])[CH:6]=1)=O.[C:16]([NH2:19])(=[S:18])[CH3:17]>C(O)C>[BrH:1].[CH3:17][C:16]1[S:18][CH:2]=[C:3]([C:5]2[CH:6]=[C:7]([OH:15])[C:8]([OH:14])=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=2)[N:19]=1

참가 물질

4

반응물 2

HCID 2723949ThioacetamideHCID 218455962-Bromo-1-(3,4-dihydroxy-5-nitro-phenyl)-ethanone

생성물 1

HCID 214591025-(2-Methyl-4-thiazolyl)-3-nitropyrocatechol hydrobromide

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 3.12 g of 2-bromo-3',4'-dihydroxy-5'-nitroacetophenone and 849.3 mg of thioacetamide are heated to boiling under reflux for 18 hours in 40 ml of ethanol. After cooling, the crystals are filtered under suction and recrystallized from methanol/isopropanol. There is obtained 5-(2-methyl-4-thiazolyl)-3-nitropyrocatechol hydrobromide of m.p. 280°-282°.

후처리

  1. temperatureare heated
  2. temperatureAfter cooling
  3. filtrationthe crystals are filtered under suction
  4. customrecrystallized from methanol/isopropanol

출처 및 근거

ORD 기록
ord-a5b3873195ae4150b60aefa9620af38f
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05389653

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