2-Aminothiazole → 5-(Imidazo[2,1-b]thiazol-6-yl)-3-nitropyrocatechol hydrobromide

HRID 274470

반응식

HRID 274470 반응식
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8]([OH:14])=[C:7]([OH:15])[CH:6]=1)=O.[NH2:16][C:17]1[S:18][CH:19]=[CH:20][N:21]=1>C(O)C>[BrH:1].[S:18]1[CH:19]=[CH:20][N:21]2[CH:2]=[C:3]([C:5]3[CH:6]=[C:7]([OH:15])[C:8]([OH:14])=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=3)[N:16]=[C:17]12

참가 물질

4

반응물 2

HCID 21552-AminothiazoleHCID 218455962-Bromo-1-(3,4-dihydroxy-5-nitro-phenyl)-ethanone

생성물 1

HCID 214591435-(Imidazo[2,1-b]thiazol-6-yl)-3-nitropyrocatechol hydrobromide

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 2.78 g of 2-bromo-3',4'-dihydroxy-5'-nitroacetophenone, 1.01 g of 2-aminothiazole and 40 ml of ethanol is heated to boiling under reflux for 23 hours. The reaction mixture is then cooled to room temperature and the crystals are removed by filtration under suction. There is obtained 5-(imidazo[2,1-b]thiazol-6-yl)-3-nitropyrocatechol hydrobromide of m.p. 286°-28820 (from methanol).

후처리

  1. temperatureis heated
  2. temperatureunder reflux for 23 hours
  3. customthe crystals are removed by filtration under suction

출처 및 근거

ORD 기록
ord-5e364a4d4d274bdaae63883439bcc2e6
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05389653

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