(2-Phenylethyl)thiourea → 3-Nitro-5-[2-(phenethylamino)-4-thiazolyl]pyrocatechol hydrobromide

HRID 274553

반응식

HRID 274553 반응식
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8]([OH:14])=[C:7]([OH:15])[CH:6]=1)=O.[CH2:16]([NH:24][C:25]([NH2:27])=[S:26])[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(O)CCC>[BrH:1].[N+:11]([C:9]1[CH:10]=[C:5]([C:3]2[N:27]=[C:25]([NH:24][CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[S:26][CH:2]=2)[CH:6]=[C:7]([OH:15])[C:8]=1[OH:14])([O-:13])=[O:12]

참가 물질

4

반응물 2

HCID 735845(2-Phenylethyl)thioureaHCID 218455962-Bromo-1-(3,4-dihydroxy-5-nitro-phenyl)-ethanone

생성물 1

HCID 214592053-Nitro-5-[2-(phenethylamino)-4-thiazolyl]pyrocatechol hydrobromide

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

A suspension of 13.8 g of 2-bromo-3',4'-dihydroxy-5'-nitroacetophenone is treated with 9.0 g of 1-(phenethyl)-2-thiourea in 150 ml of n-butanol and the mixture is heated to boiling under reflux for 3 hours. After cooling to room temperature, the crystals are filtered under suction and crystallized from n-butanol. There is obtained 3-nitro-5-[2-(phenethylamino)-4-thiazolyl]pyrocatechol hydrobromide of m.p. 249°-251°.

후처리

  1. temperaturethe mixture is heated
  2. temperatureunder reflux for 3 hours
  3. filtrationthe crystals are filtered under suction
  4. customcrystallized from n-butanol

출처 및 근거

ORD 기록
ord-aec93d097a884041a14b5325c16314da
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05389653

연결된 노트

불러오는 중…