Phosphorus oxychloride → 9-Chloro-7-dodecyl-1,2,3,4-tetrahydroacridine

HRID 274868노트

반응식

HRID 274868 반응식
[CH2:1]([C:13]1[CH:26]=[C:25]2[C:16]([N:17]=[C:18]3[C:23](=[C:24]2O)[CH2:22][CH2:21][CH2:20][CH2:19]3)=[CH:15][CH:14]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].O=P(Cl)(Cl)[Cl:30]>>[Cl:30][C:24]1[C:25]2[C:16]([N:17]=[C:18]3[C:23]=1[CH2:22][CH2:21][CH2:20][CH2:19]3)=[CH:15][CH:14]=[C:13]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])[CH:26]=2

참가 물질

3

반응물 2

HCID 24813Phosphorus oxychlorideHCID 178442815HCID 178442815, 화합물

생성물 1

HCID 200889899-Chloro-7-dodecyl-1,2,3,4-tetrahydroacridine

실험 절차

Three grams of 7-dodecyl-9-hydroxy-1,2,3,4-tetrahydroacridine was refluxed for 30 minutes in 30 mL of POCl3. At the end of this time the POCl3 was evaporated and the residue distributed between aqueous NH3 and ethyl ether. The organic phase was dried and evaporated to give 9-chloro-7-dodecyl-1,2,3,4-tetrahydroacridine (3.0 g) as a solid. A small sample was recrystallized from methanol to give fine needles, mp 36°-38°.

후처리

  1. customAt the end of this time the POCl3 was evaporated
  2. customThe organic phase was dried
  3. customevaporated

출처 및 근거

ORD 기록
ord-98a53e2b3cc04ca08e646f733569aa39
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05391553

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