HCID 178440675, 화합물 → 1,2,3,4-Tetrahydroacridine

HRID 274872노트

반응식

HRID 274872 반응식
CC([C:5]1[CH:18]=[C:17]2[C:8]([N:9]=[C:10]3[C:15](=[C:16]2O)[CH2:14][CH2:13][CH2:12][CH2:11]3)=[CH:7][CH:6]=1)(C)C>O=P(Cl)(Cl)Cl>[CH2:14]1[C:15]2[C:10](=[N:9][C:8]3[C:17]([CH:16]=2)=[CH:18][CH:5]=[CH:6][CH:7]=3)[CH2:11][CH2:12][CH2:13]1

참가 물질

3

반응물 1

HCID 178440675HCID 178440675, 화합물

생성물 1

HCID 1553151,2,3,4-Tetrahydroacridine

시약·촉매·용매 1

HCID 24813Phosphorus oxychloride용매

실험 절차

7-(1,1-Dimethylethyl)-9-hydroxy-1,2,3,4-tetrahydroacridine (9.46 g) was refluxed for 30 minutes in 50 ml of POCl3. The volatiles were evaporated and the residue was distributed between aqueous NH3 and Et2O. Concentration of the organic phase gave 8.24 g of 9-chloro-7-1,1-dimethylethyl)-1,2,3,4-tetrahydroacridine.

후처리

  1. customThe volatiles were evaporated

출처 및 근거

ORD 기록
ord-d49da7c79046488e9d1316a16e270795
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05391553

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