Sulfuryl chloride → Ethyl 2-chloro-3-oxopentanoate
반응식
S(Cl)([Cl:4])(=O)=O.[O:6]=[C:7]([CH2:14][CH3:15])[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10]>C(Cl)(Cl)Cl>[Cl:4][CH:8]([C:7](=[O:6])[CH2:14][CH3:15])[C:9]([O:11][CH2:12][CH3:13])=[O:10]참가 물질
4
실험 절차
Sulphuryl chloride (286 g.) was added dropwise to a solution of ethyl 3-oxopentanoate (300 g.) in chloroform (250 ml.) at 10°-15°. Following addition the mixture was stirred overnight at room temperature, heated under reflux for 0.5 hour and cooled. After washing with water, sodium bicarbonate and water, the solution was dried (sodium sulphate), concentrated, and fractionated to yield ethyl 2-chloro-3-oxopentanoate, b.p. 94°-96°/14 mm.
후처리
- additionaddition the mixture
- temperatureheated
- temperatureunder reflux for 0.5 hour
- temperaturecooled
- washAfter washing with water, sodium bicarbonate and water
- dry with materialthe solution was dried (sodium sulphate)
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-4bf2e9ed074343889166e28dfcebce1b
- 출처 데이터셋
- uspto-grants-1980_09
- 특허 번호
- US04221802
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