Sulfuryl chloride → Ethyl 2-chloro-3-oxopentanoate

HRID 27489

반응식

HRID 27489 반응식
S(Cl)([Cl:4])(=O)=O.[O:6]=[C:7]([CH2:14][CH3:15])[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10]>C(Cl)(Cl)Cl>[Cl:4][CH:8]([C:7](=[O:6])[CH2:14][CH3:15])[C:9]([O:11][CH2:12][CH3:13])=[O:10]

참가 물질

4

반응물 2

HCID 24648Sulfuryl chlorideHCID 78656Ethyl 3-oxovalerate

생성물 1

HCID 12923424Ethyl 2-chloro-3-oxopentanoate

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Sulphuryl chloride (286 g.) was added dropwise to a solution of ethyl 3-oxopentanoate (300 g.) in chloroform (250 ml.) at 10°-15°. Following addition the mixture was stirred overnight at room temperature, heated under reflux for 0.5 hour and cooled. After washing with water, sodium bicarbonate and water, the solution was dried (sodium sulphate), concentrated, and fractionated to yield ethyl 2-chloro-3-oxopentanoate, b.p. 94°-96°/14 mm.

후처리

  1. additionaddition the mixture
  2. temperatureheated
  3. temperatureunder reflux for 0.5 hour
  4. temperaturecooled
  5. washAfter washing with water, sodium bicarbonate and water
  6. dry with materialthe solution was dried (sodium sulphate)
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-4bf2e9ed074343889166e28dfcebce1b
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04221802

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