7-Isoquinolinol → HCID 12216281, 화합물

HRID 275025

반응식

HRID 275025 반응식
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[CH:9]2)=[CH:4][CH:3]=1.F[B-](F)(F)F.[O:17]=[N+:18]=[O:19]>C1S(=O)(=O)CCC1>[OH:1][C:2]1[C:11]([N+:18]([O-:19])=[O:17])=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[CH:9]2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 4597677-IsoquinolinolHCID 11073463Nitronium tetrafluoroborate

생성물 1

HCID 12216281HCID 12216281, 화합물

시약·촉매·용매 1

HCID 31347Sulfolane용매

실험 절차

To a 300 ml round bottom flask is added 14.5 g (0.1 mole) of 7-hydroxyisoquinoline and 100 ml of warmed tetramethylene sulfone. The brown slurry is stirred and to it is added portionwise 18.6 g (0.14 mole) of nitronium tetrafluoroborate with cooling (ice bath). The reaction is stirred for 3 hours. The reaction is then quenched with 100 ml of methanol, evaporated to dryness and triturated twice with ether to precipitate a dark solid (19.0 g, 100%).

후처리

  1. temperaturewith cooling (ice bath)
  2. stirringThe reaction is stirred for 3 hours
  3. customThe reaction is then quenched with 100 ml of methanol
  4. customevaporated to dryness
  5. customtriturated twice with ether
  6. customto precipitate a dark solid (19.0 g, 100%)

출처 및 근거

ORD 기록
ord-7be641fd55b042088dfe3ee76c5d37d9
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05391743

연결된 노트

불러오는 중…