7-Isoquinolinol → 7-Hydroxy-8-nitroisoquinoline
반응식
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[CH:9]2)=[CH:4][CH:3]=1.F[B-](F)(F)F.[O:17]=[N+:18]=[O:19]>C1S(=O)(=O)CCC1>[OH:1][C:2]1[C:11]([N+:18]([O-:19])=[O:17])=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[CH:9]2)=[CH:4][CH:3]=1참가 물질
4
실험 절차
To a 300 ml round bottom flask is added 14.5 g (0.1 mole) of 7-hydroxyisoquinoline and 100 ml of warmed tetramethylene sulfone. The brown slurry is stirred and to it is added portionwise 18.6 g (0.14 mole) of nitronium tetrafluoroborate with cooling (ice bath). The reaction is stirred for 3 hours. The reaction is then quenched with 100 ml of methanol, evaporated to dryness and triturated twice with ether to precipitate a dark solid (19.0 g, 100%).
후처리
- temperaturewith cooling (ice bath)
- stirringThe reaction is stirred for 3 hours
- customThe reaction is then quenched with 100 ml of methanol
- customevaporated to dryness
- customtriturated twice with ether
- customto precipitate a dark solid (19.0 g, 100%)
출처 및 근거
- ORD 기록
- ord-7be641fd55b042088dfe3ee76c5d37d9
- 출처 데이터셋
- uspto-grants-1995_02
- 특허 번호
- US05391743
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