Hydrochloric Acid → 2-Amino-2,3-dimethyl-N-(p-tolylsulfonyl)butyramide hydrochloride

HRID 275044노트

반응식

HRID 275044 반응식
C([NH:3][C:4]([CH3:21])([CH:18]([CH3:20])[CH3:19])[C:5]([NH:7][S:8]([C:11]1[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=1)(=[O:10])=[O:9])=[O:6])=O.[ClH:22]>CO.O>[ClH:22].[NH2:3][C:4]([CH3:21])([CH:18]([CH3:19])[CH3:20])[C:5]([NH:7][S:8]([C:11]1[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=1)(=[O:10])=[O:9])=[O:6]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 146957572-formamido-2,3-dimethyl-N-(p-tolylsulfonyl)butyramide

생성물 1

HCID 200898702-Amino-2,3-dimethyl-N-(p-tolylsulfonyl)butyramide hydrochloride

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

반응 조건

온도
80 °C

실험 절차

A suspension of 2-formamido-2,3-dimethyl-N-(p-tolylsulfonyl)butyramide (99.4 g, 0.318 mols) in 500 mL of methanol, 500 mL of water, and 500 mL of aqueous HCl 10% is heated at 80° C. until all the solid has dissolved (one hour). The reaction mixture is concentrated to 1/3 of the volume and the resulting precipitate is filtered off. After drying the title product is obtained as a white solid, having mp 161°-165° C.

후처리

  1. dissolutionhas dissolved (one hour)
  2. concentrationThe reaction mixture is concentrated to 1/3 of the volume
  3. filtrationthe resulting precipitate is filtered off
  4. dry with materialAfter drying the title product
  5. customis obtained as a white solid

출처 및 근거

ORD 기록
ord-cbc745bd6b374fb88c078822c308ec8b
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05391757

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