Ethyl orthoformate → 7-benzyl-1-methyl-3,7-dihydro-1H-purine-2,6-dione
반응식
[NH2:1][C:2]1[NH:7][C:6](=[O:8])[N:5]([CH3:9])[C:4](=[O:10])[C:3]=1[NH:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[CH:19](OCC)(OCC)OCC>CN(C=O)C>[CH3:9][N:5]1[C:4](=[O:10])[C:3]2[N:11]([CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH:19]=[N:1][C:2]=2[NH:7][C:6]1=[O:8]참가 물질
4
반응 조건
- 온도
- 110 °C
실험 절차
To 6-amino-3-methyl-5-(phenylmethylamino)pyrimidine-2,4-dione (24.6 g=0.1 mol) in DMF (125 ml) at 60° C. add triethyl orthoformate (75 ml=0.45 mol). Heat to 110° C. for 5 hr, cool in ice, filter, and wash with methanol, then ether, to obtain the title compound, m.p. 268°-71° C.
후처리
- temperaturecool in ice
- filtrationfilter
- washwash with methanol
출처 및 근거
- ORD 기록
- ord-a1f1974372d84433be00f25b58dcdfbe
- 출처 데이터셋
- uspto-grants-1995_02
- 특허 번호
- US05393755
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