Caprolactam → hexanoic acid, 6-amino-, monosodium salt

HRID 275501

반응식

HRID 275501 반응식
[C:1]1(=[O:8])[NH:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(Cl)(=O)CCCCC(Cl)=[O:15].[OH-].[Na+:20]>>[NH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][C:1]([O-:8])=[O:15].[Na+:20]

참가 물질

4

반응물 3

HCID 7768CaprolactamHCID 14798Sodium HydroxideHCID 61034Adipoyl chloride

생성물 1

HCID 23663648hexanoic acid, 6-amino-, monosodium salt수율 70%

실험 절차

The literature has described various methods for preparation of TOCAP and related compounds. German Patent 949,568 (Kruckenberg) discloses the reaction of caprolactam with various acyl halides including adipoyl dichloride in the presence of sodium hydroxide. Once sodium 6-aminocaproate has formed, the reactor is charged with a first portion acyl halide, sodium hydroxide and then a final portion acyl halide. A related method is reported by Zinner et al in J. Prakt. Chem. 17, 147-153 (1962). The procedure requires the addition of all the sodium hydroxide to be charged to the reaction vessel at the beginning of the synthesis. The reported yield is 70% of theory.

후처리

  1. customfor preparation of TOCAP

출처 및 근거

ORD 기록
ord-316f4a5c879942108f6bfa368ea58fce
출처 데이터셋
uspto-grants-1995_02
특허 번호
US05393902

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