참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Imidazole | HCID 795 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | Iodide Ion | HCID 30165 | — |
| 반응물 | 2-(2,3-dihydro-1H-inden-2-yl)ethanol | HCID 10352000 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 2-(2-Iodoethyl)indane | HCID 18545833 | 87.7% |
반응 단계
A mixture of 2-(indan-2-yl)ethanol (19.3 g), imidazole (12.1 g), triphenylphosphine (34.3 g), and toluene (250 ml) was heated to 90° C. To this mixture, iodide (33.2 g) was added, and the resulting mixture was stirred at 90° C. for 20 min. The mixture was allowed to cool to room temperature. filtered, and concentrated in vacuo. The residue was purified on silica gel eluted with ethyl acetate-heptane (1:4) to give an oil (28.4 g, 87%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06352988B2 |
|---|
| 출처 데이터셋 | uspto-grants-2002_03 |
|---|
| ORD ID | ord-9d7eea3300c943ff991280db890d539d |
|---|
| 출처 메모 | uspto-grants-2002_03 |
|---|
