反应详情

温度

90 °C

A mixture of 2-(indan-2-yl)ethanol (19.3 g), imidazole (12.1 g), triphenylphosphine (34.3 g), and toluene (250 ml) was heated to 90° C. To this mixture, iodide (33.2 g) was added, and the resulting mixture was stirred at 90° C. for 20 min. The mixture was allowed to cool to room temperature. filtered, and concentrated in vacuo. The residue was purified on silica gel eluted with ethyl acetate-heptane (1:4) to give an oil (28.4 g, 87%).

1. temperatureto cool to room temperature
2. filtrationfiltered
3. concentrationconcentrated in vacuo
4. customThe residue was purified on silica gel
5. washeluted with ethyl acetate-heptane (1:4)