Rubitecan → 9-Aminocamptothecin
반응식
[CH3:1][CH2:2][C@@:3]1([OH:29])[C:8](=[O:9])[O:7][CH2:6][C:5]2[C:10]([N:12]3[C:16](=[CH:17][C:4]1=2)[C:15]1[N:18]=[C:19]2[C:24](=[CH:25][C:14]=1[CH2:13]3)[C:23]([N+:26]([O-])=O)=[CH:22][CH:21]=[CH:20]2)=[O:11]>[Fe].Cl>[CH3:1][CH2:2][C@@:3]1([OH:29])[C:8](=[O:9])[O:7][CH2:6][C:5]2[C:10]([N:12]3[C:16](=[CH:17][C:4]1=2)[C:15]1[N:18]=[C:19]2[C:24]([C:23]([NH2:26])=[CH:22][CH:21]=[CH:20]2)=[CH:25][C:14]=1[CH2:13]3)=[O:11]참가 물질
4
실험 절차
As a specific example, approximately 0.5 g of the 9-nitrocamptothecin derivatives can be mixed with about 100 mg of iron powder and 20 ml of 10% HCl to form the 9-aminocamptothecin derivative.
출처 및 근거
- ORD 기록
- ord-c11bf889a4b0456b843c0333be138537
- 출처 데이터셋
- uspto-grants-2002_03
- 특허 번호
- US06352996B1
반응 노트
불러오는 중…