Rubitecan → 9-Aminocamptothecin

HRID 275729

반응식

HRID 275729 반응식
[CH3:1][CH2:2][C@@:3]1([OH:29])[C:8](=[O:9])[O:7][CH2:6][C:5]2[C:10]([N:12]3[C:16](=[CH:17][C:4]1=2)[C:15]1[N:18]=[C:19]2[C:24](=[CH:25][C:14]=1[CH2:13]3)[C:23]([N+:26]([O-])=O)=[CH:22][CH:21]=[CH:20]2)=[O:11]>[Fe].Cl>[CH3:1][CH2:2][C@@:3]1([OH:29])[C:8](=[O:9])[O:7][CH2:6][C:5]2[C:10]([N:12]3[C:16](=[CH:17][C:4]1=2)[C:15]1[N:18]=[C:19]2[C:24]([C:23]([NH2:26])=[CH:22][CH:21]=[CH:20]2)=[CH:25][C:14]=1[CH2:13]3)=[O:11]

참가 물질

4

반응물 1

HCID 472335Rubitecan

생성물 1

HCID 724029-Aminocamptothecin

시약·촉매·용매 2

HCID 23925Iron촉매HCID 313Hydrochloric Acid용매

실험 절차

As a specific example, approximately 0.5 g of the 9-nitrocamptothecin derivatives can be mixed with about 100 mg of iron powder and 20 ml of 10% HCl to form the 9-aminocamptothecin derivative.

출처 및 근거

ORD 기록
ord-c11bf889a4b0456b843c0333be138537
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06352996B1

연결된 노트

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