Hydrogen Bromide → Heptaacetate bromide

HRID 27585

반응식

HRID 27585 반응식
[OH:1][CH:2]1[O:10][C@H](CO)[C@@H](O)[C@H](O)[C@H:3]1O.C(Cl)Cl.[BrH:16]>C(O)(=O)C>[Br-:16].[C:2]([O-:10])(=[O:1])[CH3:3].[C:2]([O-:10])(=[O:1])[CH3:3].[C:2]([O-:10])(=[O:1])[CH3:3].[C:2]([O-:10])(=[O:1])[CH3:3].[C:2]([O-:10])(=[O:1])[CH3:3].[C:2]([O-:10])(=[O:1])[CH3:3].[C:2]([O-:10])(=[O:1])[CH3:3]

참가 물질

5

반응물 3

HCID 260Hydrogen BromideHCID 5793D-GlucoseHCID 6344Dichloromethane2회

생성물 1

HCID 86737203Heptaacetate bromide

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Glc 1β,4 glc is converted to its octaacetate form by conventional methods as disclosed in Methods of Carbohydrate Chemistry 1, 334. A 20 g. portion of this octaacetate is dissolved in 200 ml. of methylene chloride and the solution is cooled to 0° C. An 80 ml. portion of 32% hydrobromic acid in glacial acetic acid is added and the mixture is allowed to stand in an ice bath for 2 hours. The mixture is then poured into crushed ice and diluted with 200 ml. of methylene chloride. The organic layer is separated, washed repeatedly with ice water until neutral, dried over anhydrous sodium sulfate and evaporated in vacuo, giving glc 1β,4 glc heptaacetate bromide as a white solid.

후처리

  1. additionThe mixture is then poured
  2. custominto crushed ice
  3. additiondiluted with 200 ml
  4. customThe organic layer is separated
  5. washwashed repeatedly with ice water until neutral,
  6. dry with materialdried over anhydrous sodium sulfate
  7. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-6a50caf659d14d7391d1c254f7af3fa4
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04221907

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