Methyl iodide → N-(2-(4-Methoxyphenyl)ethyl)acetamide

HRID 275898

반응식

HRID 275898 반응식
[C:1](=O)([O-])[O-].[K+].[K+].IC.[OH:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][NH:18][C:19](=[O:21])[CH3:20])=[CH:12][CH:11]=1>C(O)C.C(OCC)(=O)C>[CH3:1][O:9][C:10]1[CH:11]=[CH:12][C:13]([CH2:16][CH2:17][NH:18][C:19](=[O:21])[CH3:20])=[CH:14][CH:15]=1

참가 물질

6

반응물 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 121051N-Acetyltyramine

생성물 1

HCID 584258N-(2-(4-Methoxyphenyl)ethyl)acetamide수율 61%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 8857Ethyl Acetate용매

실험 절차

Potassium carbonate (3.5 g, 25.5 mol) and iodomethane(2.0 ml, 31.9 mmol) was added to a solution of N-(4-hydroxyphenylethyl)acetamide (4.4 g, 24.6 mmol) in ethanol(2.4 ml), which was then refluxed for 12 hours. The resulting solid was filtered and washed with ethanol. The filtrate was concentrated to give oily residue, which was diluted with ethyl acetate and washed with water. The separated organic layer was concentrated and the resulting solid was suspended in ethylether, filtered, and dried to give 2.9 g of the titled compound.

후처리

  1. temperaturewas then refluxed for 12 hours
  2. filtrationThe resulting solid was filtered
  3. washwashed with ethanol
  4. concentrationThe filtrate was concentrated
  5. customto give oily residue, which
  6. washwashed with water
  7. concentrationThe separated organic layer was concentrated
  8. filtrationfiltered
  9. customdried

출처 및 근거

ORD 기록
ord-5c11490e8aac4d3482257346829179eb
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06352993B1

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