Hydrochloric Acid → HCID 178494701, 화합물

HRID 275901노트

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HRID 275901 반응식
N[C:2]1[N:7]=[C:6]([OH:8])[C:5]([CH3:9])=[C:4]([CH2:10][O:11][CH3:12])[N:3]=1.Cl.N([O-])=[O:15].[Na+]>O>[OH:15][C:2]1[N:7]=[C:6]([OH:8])[C:5]([CH3:9])=[C:4]([CH2:10][O:11][CH3:12])[N:3]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 23668193Sodium NitriteHCID 178494689HCID 178494689, 화합물

생성물 1

HCID 178494701HCID 178494701, 화합물수율 55.1%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
70 °C

실험 절차

2-amino-4-hydroxy-6-methoxymethyl-5-methylpyrimidine (2.7 g, 16 mmol) was added to 20% aqueous hydrochloric acid solution (7 ml), and heated to 70° C. A solution of sodium nitrite (2.3 g, 33.3 mmol) in water was added dropwise to a reaction mixture while maintaining the reaction temperature under 70° C. The reaction mixture was cooled to a room temperature. The resulting solid was filtered and dried to give 1.5 g of the titled compound.

후처리

  1. temperaturewhile maintaining the reaction temperature under 70° C
  2. temperatureThe reaction mixture was cooled to a room temperature
  3. filtrationThe resulting solid was filtered
  4. customdried

출처 및 근거

ORD 기록
ord-03a96151fb5f478b94ae171dae7024a8
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06352993B1

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