Chloral → alpha-Trichloromethyl-2-thiophenemethanol

HRID 27591

반응식

HRID 27591 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[CH:2]1.[Cl:6][C:7]([Cl:11])([Cl:10])[CH:8]=[O:9]>CCCCCCC>[Cl:6][C:7]([Cl:11])([Cl:10])[CH:8]([C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)[OH:9]

참가 물질

4

반응물 2

HCID 6407ChloralHCID 8030Thiophene

생성물 1

HCID 12566320alpha-Trichloromethyl-2-thiophenemethanol수율 20%

시약·촉매·용매 1

HCID 8900Heptane용매

실험 절차

Thiophene (4.2 g, 50 mmol) and trichloroacetaldehyde (7.35 g, 50 mmol) were dissolved in n-heptane (25 ml). The solution was heated under reflux for 3.5 hr. under a Soxleht apparatus in which Amberlyst 15 (4.2 g) had been placed. After cooling, the n-heptane solution was concentrated, and the residue was purified by distillation to give 2.32 g of α-trichloromethyl-2-thiophenemethanol boiling at 98°-100° C./1.0 mmHg.

후처리

  1. temperatureThe solution was heated
  2. temperatureunder reflux for 3.5 hr
  3. temperatureAfter cooling
  4. concentrationthe n-heptane solution was concentrated
  5. distillationthe residue was purified by distillation

출처 및 근거

ORD 기록
ord-28b3a49b4b8d4b40a1cbd8ddf9546e9f
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04221915

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