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Triethylamine → 6-Methoxymethyl-5-methyl-2-(4-fluoro-2-methylphenylamino)-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine hydrochloride

HRID 275933
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HRID 275933 반응식
[CH3:1][C:2]1[CH:8]=[C:7]([F:9])[CH:6]=[CH:5][C:3]=1[NH2:4].C(N(CC)CC)C.[CH3:17][O:18][CH2:19][C:20]1[N:25]=[C:24]([Cl:26])[N:23]=[C:22]([N:27]2[CH2:36][CH2:35][C:34]3[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=3)[CH2:28]2)[C:21]=1[CH3:37]>CN(C)C=O>[ClH:26].[CH3:17][O:18][CH2:19][C:20]1[N:25]=[C:24]([NH:4][C:3]2[CH:5]=[CH:6][C:7]([F:9])=[CH:8][C:2]=2[CH3:1])[N:23]=[C:22]([N:27]2[CH2:36][CH2:35][C:34]3[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=3)[CH2:28]2)[C:21]=1[CH3:37]
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참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 679824-Fluoro-2-methylanilineHCID 183157876-Methoxymethyl-5-methyl-2-chloro-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine

생성물 1

HCID 183157256-Methoxymethyl-5-methyl-2-(4-fluoro-2-methylphenylamino)-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine hydrochloride수율 58.3%

시약·촉매·용매 1

HCID 6228
Dimethylformamide
용매

실험 절차

After 2-methyl-4-fluoroaniline(0.51 g, 4.5 mmol) and triethylamine (0.63 ml, 4.5 mmol) were added to a solution of 6-methoxymethyl-5-methyl-2-chloro-4-(1,2,3,4-tetrahydroisoquinolin-2-yl) pyrimidine(0.9 g, 3 mmol) in dimethylformamide (5 ml), 750 mg of the titled compound was obtained in accordance with the same procedure as in Step 2 of Example 25.

출처 및 근거

ORD 기록
ord-4dd83efb903749b8b241e0ad758a2b9e
출처 데이터셋
uspto-grants-2002_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06352993B1

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