Thionyl Chloride → 1-(Chloromethyl)-4-phenoxybenzene

HRID 276076

반응식

HRID 276076 반응식
S(Cl)([Cl:3])=O.[O:5]([C:12]1[CH:19]=[CH:18][C:15]([CH2:16]O)=[CH:14][CH:13]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>>[O:5]([C:12]1[CH:19]=[CH:18][C:15]([CH2:16][Cl:3])=[CH:14][CH:13]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 826195(4-Phenoxyphenyl)methanol

생성물 1

HCID 5209941-(Chloromethyl)-4-phenoxybenzene수율 97.2%

반응 조건

온도
80 °C

실험 절차

Thionyl chloride (13.34 g) was added to 4.06 g of 4-phenoxybenzyl alcohol, and the mixture was stirred at 80° C. for 3.5 hours. After the completion of the concentration, the reaction mixture was extracted with ethyl acetate and with water. The organic layer was concentrated to give 4.31 g of 4-phenoxybenzyl chloride.

후처리

  1. concentrationAfter the completion of the concentration
  2. extractionthe reaction mixture was extracted with ethyl acetate and with water
  3. concentrationThe organic layer was concentrated

출처 및 근거

ORD 기록
ord-e48630886bf3471b8d19ba088efbd56b
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06352985B1

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