Acetone → 5-Chloro-2-(4-methoxyphenoxy)benzenamine

HRID 27623노트

반응식

HRID 27623 반응식
COC1C=CC([C:9]2[C:10]([N+]([O-])=O)=[C:11]([O:16][C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[C:19](C4C=CC(OC)=CC=4)[C:18]=3[N+:32]([O-])=O)[CH:12]=[CH:13][C:14]=2Cl)=CC=1.C[C:39](C)=[O:40].S(S([O-])=O)([O-])=O.[Na+].[Na+]>O>[Cl:23][C:20]1[CH:21]=[CH:22][C:17]([O:16][C:11]2[CH:10]=[CH:9][C:14]([O:40][CH3:39])=[CH:13][CH:12]=2)=[C:18]([CH:19]=1)[NH2:32]

참가 물질

5

반응물 3

HCID 180AcetoneHCID 24489Sodium DithioniteHCID 57238430HCID 57238430, 화합물

생성물 1

HCID 24878325-Chloro-2-(4-methoxyphenoxy)benzenamine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

An 80.0 g. portion of the above nitro derivative in 800 ml. of acetone is added to 320.0 g. of sodium hydrosulfite in 800 ml. of water. The mixture is heated to reflux on a steam bath for one hour, cooled and extracted with benzene. The benzene extract is washed with water, dried over anhydrous sodium sulfate, and evaporated in vacuo to a yellow oil. Treatment in hexane, with cooling produces crystals of 5-chloro-2-(p-methoxyphenoxy)-aniline.

후처리

  1. temperatureThe mixture is heated
  2. temperatureto reflux on a steam bath for one hour
  3. temperaturecooled
  4. extractionextracted with benzene
  5. extractionThe benzene extract
  6. washis washed with water
  7. dry with materialdried over anhydrous sodium sulfate
  8. customevaporated in vacuo to a yellow oil
  9. temperatureTreatment in hexane, with cooling

출처 및 근거

ORD 기록
ord-88a787f9ffe8471d837f061f01e8337d
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04221714

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