Thionyl Chloride → (4S)-2-(4-cyano-2-ethylphenylimino)-4-isobutyl-1,3-thiazolidine

HRID 276467

반응식

HRID 276467 반응식
O[CH2:2][C@@H:3]([NH2:8])[CH2:4][CH:5]([CH3:7])[CH3:6].O=S(Cl)Cl.[C:13]([C:15]1[CH:20]=[CH:19][C:18]([N:21]=[C:22]=[S:23])=[C:17]([CH2:24][CH3:25])[CH:16]=1)#[N:14]>>[C:13]([C:15]1[CH:20]=[CH:19][C:18]([N:21]=[C:22]2[NH:8][C@@H:3]([CH2:4][CH:5]([CH3:7])[CH3:6])[CH2:2][S:23]2)=[C:17]([CH2:24][CH3:25])[CH:16]=1)#[N:14]

참가 물질

4

반응물 3

HCID 24386Thionyl ChlorideHCID 111307L-LeucinolHCID 183161022-Ethyl-4-cyanophenyl isothiocyanate

생성물 1

HCID 178436590(4S)-2-(4-cyano-2-ethylphenylimino)-4-isobutyl-1,3-thiazolidine

실험 절차

(1S)-1-(Hydroxymethyl)-3-methylbutylamine was reacted with SOCl2 followed by 4-cyano-2-ethylphenyl isothiocyanate according to Method C2a to give (4S)-2-(4-cyano-2-ethylphenylimino)-4-isobutyl-1,3-thiazolidine. The thiazolidine was reacted with isobutyl bromide according to Method D2a to give (4S)-2-(4-cyano-2-ethylphenylimino)-3,4-diisobutyl-1,3-thiazolidine.

출처 및 근거

ORD 기록
ord-729bc953ecec46e080796b4cb27e7f59
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06353006B1

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