Ethanolamine → 9-(2-Methyl-4-nitrophenylimino)-1-aza-8-thiabicyclo[4.3.0]nonane

HRID 276496

반응식

[NH:1]1[CH2:10][CH2:9][CH2:8][CH2:7][CH:2]1[C:3](OC)=O.OCCN.[Cl-].ClCC1CCCC[NH2+]1.[CH3:24][C:25]1[CH:30]=[C:29]([N+:31]([O-:33])=[O:32])[CH:28]=[CH:27][C:26]=1[N:34]=[C:35]=[S:36]>>[CH3:24][C:25]1[CH:30]=[C:29]([N+:31]([O-:33])=[O:32])[CH:28]=[CH:27][C:26]=1[N:34]=[C:35]1[N:1]2[CH:2]([CH2:7][CH2:8][CH2:9][CH2:10]2)[CH2:3][S:36]1

참가 물질

반응물 4

HCID 700Ethanolamine

HCID 1456212-Methyl-4-nitrophenyl isothiocyanate

HCID 3463753Methyl pipecolinate

HCID 178478436HCID 178478436, 화합물2회

생성물 1

HCID 183163059-(2-Methyl-4-nitrophenylimino)-1-aza-8-thiabicyclo[4.3.0]nonane

실험 절차

2-Piperidenemethanol was made from methyl pipecolinate as described in Method B1b. The 2-hydroxyethylamine was converted to 2-chloromethylpiperidinium chloride according to Method B7a. 2-Methyl4-nitrophenyl isothiocyanate was reacted with 2-chloromethylpiperidinium chloride according according to Method C1a to give 9-(2-methyl-4-nitrophenylimino)-1-aza-8-thiabicyclo[4.3.0]nonane.

출처 및 근거

ORD 기록: ord-c951ff5debe4466ebad410dd29a6a027
출처 데이터셋: uspto-grants-2002_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06353006B1

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