Cyclohexanecarboxylic acid → N-(5-Phenylthiophen-2-yl)cyclohexanecarboxamide

HRID 27666

반응식

HRID 27666 반응식
C([C:4]1[C:8](C)=[C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[S:6][C:5]=1[NH:16][C:17]([CH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1)=[O:18])(O)=O.[Li]I.O.O.C1(C(O)=O)CCCCC1>N1C(C)=CC(C)=CC=1C>[C:10]1([C:7]2[S:6][C:5]([NH:16][C:17]([CH:19]3[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]3)=[O:18])=[CH:4][CH:8]=2)[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

참가 물질

5

반응물 3

HCID 7413Cyclohexanecarboxylic acidHCID 70592634N-(3-carboxy-methyl-5-phenyl-2-thienyl)-cyclohexane carboxamideHCID 178526965HCID 178526965, 화합물

생성물 1

HCID 23341601N-(5-Phenylthiophen-2-yl)cyclohexanecarboxamide

시약·촉매·용매 1

HCID 79532,4,6-Trimethylpyridine용매

실험 절차

This compound (m.p. 174° C.) was prepared from N-(3-carboxy-methyl-5-phenyl-2-thienyl)-cyclohexane carboxamide (31.1 g, 0.1 mole) and LiI.2H2O (48.1 g, 0.32 mole) by refluxing in collidine (125 ml.) according to the procedure of Example 53 (a). This compound was also prepared according to the procedure of Example 53(b), using cyclohexane carboxylic acid as the acylating agent. The products of the two processes were spectrally identical and had a melting point of 175° C.

후처리

  1. customThis compound was also prepared

출처 및 근거

ORD 기록
ord-fa69975da3e14d579e8308f5c3d04eb7
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04222946

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