Hydrochloric Acid → HCID 87455353, 화합물

HRID 276715노트

반응식

HRID 276715 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]([OH:12])=O)=[CH:4][CH:3]=1.[NH2:13][C@H:14]([C:19]([NH:21][CH2:22][C:23](O)=O)=[O:20])[CH2:15][CH:16]([CH3:18])[CH3:17].Cl.C1C=CC2N(O)N=[N:33]C=2C=1>CN(C)C=O.C(N(CC)CC)C>[C:23]([CH2:22][NH:21][C:19](=[O:20])[CH:14]([NH:13][C:10](=[O:12])[CH2:9][NH:8][C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)[CH2:15][CH:16]([CH3:18])[CH3:17])#[N:33]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 757711-HydroxybenzotriazoleHCID 97364Leu-GlyHCID 2307172-((4-Chlorophenyl)amino)acetic acid

생성물 1

HCID 87455353HCID 87455353, 화합물

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8471Triethylamine용매

실험 절차

(4-Chloro-phenylamino)-acetic acid (0.5 g) and H-Leu-Gly((CN).HCl (0.55 g) are dissolved in dimethylformamide (4 ml). HOBt (0.44 g), WSCD.HCI (0.54 g), triethylamine (0.37 ml) is added and the reaction mixture is stirred for 18 hours. After evaporation of the solvent, the residue is extracted with ethyl acetate. The extract is washed with 10% citric acid, brine, sodium bicarbonate, brine and dried over magnesium sulfate and evaporated. The crude product is slurried in diethylether and the solid filtered of and dried (vacuum) yielding a white powder with mp. 131-134° C.

후처리

  1. customAfter evaporation of the solvent
  2. extractionthe residue is extracted with ethyl acetate
  3. washThe extract is washed with 10% citric acid, brine, sodium bicarbonate, brine
  4. dry with materialdried over magnesium sulfate
  5. customevaporated
  6. filtrationthe solid filtered of and
  7. customdried (vacuum)
  8. customyielding a white powder with mp. 131-134° C.

출처 및 근거

ORD 기록
ord-2b7e6c65f7ab4df38e565224e16e81c4
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06353017B1

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