Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrogen Bromide → 4-(4-Butyl-1-piperazinyl)phenol monohydrobromide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrogen Bromide | HCID 260 | — |
| 반응물 | 1-Butyl-4-(4-methoxyphenyl)piperazine dihydrochloride | HCID 20519334 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 4-(4-Butyl-1-piperazinyl)phenol monohydrobromide | HCID 20519295 | 81% |
반응 단계
A mixture of 12.5 parts of 1-butyl-4-(4-methoxyphenyl)-piperazine dihydrochloride and 150 parts of hydrobromic acid solution 48% in glacial acetic acid is stirred and refluxed overnight. The reaction mixture is evaporated and the residue is triturated in 2-propanone. The product is filtered off and crystallized from water, yielding 13.1 parts (81%) of 4-(4-butyl-1-piperazinyl)phenol monohydrobromide; mp. 281.9° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04223036 |
| 출처 데이터셋 | uspto-grants-1980_09 |
| ORD ID | ord-445a20017a9e4fc9962886c63d95be3f |
| 출처 메모 | uspto-grants-1980_09 |