反应详情

A mixture of 12.5 parts of 1-butyl-4-(4-methoxyphenyl)-piperazine dihydrochloride and 150 parts of hydrobromic acid solution 48% in glacial acetic acid is stirred and refluxed overnight. The reaction mixture is evaporated and the residue is triturated in 2-propanone. The product is filtered off and crystallized from water, yielding 13.1 parts (81%) of 4-(4-butyl-1-piperazinyl)phenol monohydrobromide; mp. 281.9° C.

1. temperaturerefluxed overnight
2. customThe reaction mixture is evaporated
3. customthe residue is triturated in 2-propanone
4. filtrationThe product is filtered off
5. customcrystallized from water