Water → 2-(4-Benzyloxyphenylmethylene)-4-methyl-3-oxopentanamide

HRID 277567

반응식

HRID 277567 반응식
[CH3:1][CH:2]([CH3:15])[C:3](=[O:14])[CH2:4][C:5]([NH:7]C1C=CC=CC=1)=[O:6].[CH2:16]([O:23][C:24]1[CH:31]=[CH:30][C:27]([CH:28]=O)=[CH:26][CH:25]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.N1C=CC=CC=1.O>C1(C)C(C)=CC=CC=1>[CH2:16]([O:23][C:24]1[CH:31]=[CH:30][C:27]([CH:28]=[C:4]([C:3](=[O:14])[CH:2]([CH3:15])[CH3:1])[C:5]([NH2:7])=[O:6])=[CH:26][CH:25]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 1049PyridineHCID 78109Benzaldehyde, 4-(phenylmethoxy)-HCID 102198994-methyl-3-oxo-N-phenylpentanamide

생성물 1

HCID 540483912-(4-Benzyloxyphenylmethylene)-4-methyl-3-oxopentanamide

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

Step A—A solution of 4-methyl-N-phenyl-3-oxopentanamide, 12, (5 mmol), 4-benzyloxybenzaldehyde (5 mmol) and pyridine (1 mL) in xylene (100 mL) is heated at reflux, with azeotropic removal of water. The progress of the reaction is monitored by tlc. When the reaction is complete, the solvent is removed under reduced pressure, and the residue is chromatographed to afford 2-(4-benzyloxyphenylmethylene)-4-methyl-3-oxopentanamide, 13, (R=4-benzyloxy).

후처리

  1. customthe solvent is removed under reduced pressure
  2. customthe residue is chromatographed

출처 및 근거

ORD 기록
ord-dd175ec9fb224853972661988935f5aa
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06355810B1

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