Water → 5-Cyano-6-methyl-2-[(1-methylpropyl)amino]-3-pyridine-carboxylic acid, ethyl ester

HRID 27762

반응식

HRID 27762 반응식
Cl[C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][C:5]([C:13]#[N:14])=[C:4]([CH3:15])[N:3]=1.[CH:16]([NH2:20])([CH2:18][CH3:19])[CH3:17].O>C(O)C>[C:13]([C:5]1[CH:6]=[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[C:2]([NH:20][CH:16]([CH3:17])[CH2:18][CH3:19])=[N:3][C:4]=1[CH3:15])#[N:14]

참가 물질

5

반응물 3

HCID 962WaterHCID 24874Sec-ButylamineHCID 2758816Ethyl 2-chloro-5-cyano-6-methylnicotinate

생성물 1

HCID 867372195-Cyano-6-methyl-2-[(1-methylpropyl)amino]-3-pyridine-carboxylic acid, ethyl ester

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

22.4 g of 2-chloro-5-cyano-6-methyl-3-pyridine-carboxylic acid, ethyl ester (1 mol) of Example 1(b) are treated in 100 ml of ethanol with 15 g sec. butylamine at reflux temperature with stirring. After the addition of the amine is completed, the solution is poured into 200 ml of cold water, and the amino compound is filtered off. Yield 22 g (84%); m.p. 55°-57° C.

후처리

  1. temperatureat reflux temperature
  2. filtrationthe amino compound is filtered off

출처 및 근거

ORD 기록
ord-8ae000ca848e414ea1ff080f0b71df04
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04223142

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