1,4-Dioxane → 1-(4-Benzyloxyphenoxy)-3-[4-(2-methoxy-5-methylphenyl)-1-piperazinyl]propan-2-ol

HRID 277648

반응식

HRID 277648 반응식
[CH2:1]([O:8][C:9]1[CH:19]=[CH:18][C:12]([O:13][CH2:14][CH:15]2[O:17][CH2:16]2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O1CCOCC1.Cl.Cl.[CH3:28][O:29][C:30]1[CH:35]=[CH:34][C:33]([CH3:36])=[CH:32][C:31]=1[N:37]1[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]1>C(N(CC)CC)C>[CH2:1]([O:8][C:9]1[CH:19]=[CH:18][C:12]([O:13][CH2:14][CH:15]([OH:17])[CH2:16][N:40]2[CH2:39][CH2:38][N:37]([C:31]3[CH:32]=[C:33]([CH3:36])[CH:34]=[CH:35][C:30]=3[O:29][CH3:28])[CH2:42][CH2:41]2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 312751,4-DioxaneHCID 119882((p-(Benzyloxy)phenoxy)methyl)oxiraneHCID 22625397HCID 22625397, 화합물

생성물 1

HCID 226254051-(4-Benzyloxyphenoxy)-3-[4-(2-methoxy-5-methylphenyl)-1-piperazinyl]propan-2-ol수율 89.5%

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

Using 1.37 g of 1-(4-benzyloxyphenoxy)-2,3-epoxypropane, 50 ml of dioxane, 1.49 g of 1-(2-methoxy-5-methylphenyl)piperazine dihydrochloride and 1.6 ml of triethylamine, reaction and workup were carried out as in Example 1-A. Purification by column chromatography (silica gel, elution with ethyl acetate:hexane=1:1) gave 2.21 g of pale yellow oil.

후처리

  1. customPurification
  2. washby column chromatography (silica gel, elution with ethyl acetate:hexane=1:1)

출처 및 근거

ORD 기록
ord-69d41a5bc4b94670b9a110e6d04c642f
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06358515B2

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