Methylhydroquinone → 4-Benzoyloxy-2-methylphenol

반응식

[CH3:1][C:2]1[CH:8]=[C:7]([OH:9])[CH:6]=[CH:5][C:3]=1[OH:4].[C:10](Cl)(=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[C:10]([O:9][C:7]1[CH:6]=[CH:5][C:3]([OH:4])=[C:2]([CH3:1])[CH:8]=1)(=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

반응물 2

HCID 7253Methylhydroquinone

HCID 7412Benzoyl chloride

생성물 1

HCID 146503304-Benzoyloxy-2-methylphenol수율 68.2%

실험 절차

Using 2.5 g of methylhydroquinone and 2.8 g of benzoyl chloride, the procedure in Reference Example was followed. Recrystallization from ethanol-isopropyl ether gave 3.1 g of 4-benzoyloxy-2-methylphenol as white crystals, m.p. 120-122° C. Then, using 2.3 g of the crystals, 1.4 g of anhydrous potassium carbonate, 4.6 g of chloromethyloxirane and 1.9 g of 1-(2-methoxyphenyl)piperazine, the procedures of Examples 3 and 4 were followed to give 3.2 g of white crystals, m.p. 192-194° C. (decomp.).

후처리

customRecrystallization from ethanol-isopropyl ether

출처 및 근거

ORD 기록: ord-1e798493ce78462eb830a138848a9708
출처 데이터셋: uspto-grants-2002_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06358515B2

반응 노트

불러오는 중…