Toluene → HCID 22625918, 화합물

HRID 277779

반응식

HRID 277779 반응식
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:4]=[C:5]([CH2:9][CH2:10][NH2:11])[CH:6]=[CH:7][CH:8]=1.CN(C1C2C(N(C)C)=CC=CC=2C=CC=1)C.[C:30](Cl)(Cl)=[O:31].C1(C)C=CC=CC=1>C(Cl)Cl>[F:1][C:2]([F:12])([F:13])[C:3]1[CH:4]=[C:5]([CH2:9][CH2:10][N:11]=[C:30]=[O:31])[CH:6]=[CH:7][CH:8]=1

참가 물질

6

반응물 4

HCID 1140TolueneHCID 6371PhosgeneHCID 88675Proton spongeHCID 104223Phenethylamine, m-trifluoromethyl-

생성물 1

HCID 22625918HCID 22625918, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
25 °C

실험 절차

To a methylene chloride solution of commercially available 2-(3-trifluoromethylphenyl)ethylamine (5.65 mmol) at 0° C. was added solid Proton sponge (5.65 mmol) then a 20% solution of phosgene in toluene (5.65 mmol). The solution was stirred at 25° C. for 1 hour and then washed with 1N HCl (40 mL). The methylene chloride was then dried with sodium sulfate and evaporated. 1H-NMR (CDCl3): 7.5 ppm (m, 4H); 3.6 ppm (t, 2H); 2.95 ppm (t, 2H).

후처리

  1. washwashed with 1N HCl (40 mL)
  2. dry with materialThe methylene chloride was then dried with sodium sulfate
  3. customevaporated

출처 및 근거

ORD 기록
ord-14752c278bc741549bd1462504deb75d
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06358956B1

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