Toluene → 2-Fluoro-5-trifluoromethylbenzylisocyanate

HRID 277780노트

반응식

HRID 277780 반응식
[F:1][C:2]1[CH:9]=[CH:8][C:7]([C:10]([F:13])([F:12])[F:11])=[CH:6][C:3]=1[CH2:4][NH2:5].CN(C1C2C(N(C)C)=CC=CC=2C=CC=1)C.[C:30](Cl)(Cl)=[O:31].C1(C)C=CC=CC=1>C(Cl)Cl>[F:1][C:2]1[CH:9]=[CH:8][C:7]([C:10]([F:11])([F:12])[F:13])=[CH:6][C:3]=1[CH2:4][N:5]=[C:30]=[O:31]

참가 물질

6

반응물 4

HCID 1140TolueneHCID 6371PhosgeneHCID 88675Proton spongeHCID 5338392-Fluoro-5-(trifluoromethyl)benzylamine

생성물 1

HCID 226259052-Fluoro-5-trifluoromethylbenzylisocyanate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
25 °C

실험 절차

To a methylene chloride solution of commercially available 2-fluoro-5-trifluoromethyl benzyl amine(5.23 mmol) at 0° C. was added solid Proton sponge (5.23 mmol) then a 20% solution of phosgene in toluene (5.23 mmol). The solution was stirred at 25° C. for 1 hour and then washed with 1N HCl (40 mL). The methylene chloride was then dried with sodium sulfate and evaporated to provide the title compound. 1H-NMR (CDCl3): 7.7 ppm (t, 1H); 7.60 ppm (m, 1H); 7.2 ppm (m, 1H); 4.64 ppm (s, 2H).

후처리

  1. washwashed with 1N HCl (40 mL)
  2. dry with materialThe methylene chloride was then dried with sodium sulfate
  3. customevaporated

출처 및 근거

ORD 기록
ord-d8cf9279991d4c7888dd011fbdfbe3ab
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06358956B1

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