Hydrochloric Acid → 3-(3-Bromophenyl)acrylic acid

HRID 2778

반응식

HRID 2778 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=O.C(O)(=O)[CH2:11][C:12]([OH:14])=[O:13].Cl>N1CCCCC1.N1C=CC=CC=1>[Br:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:11][C:12]([OH:14])=[O:13])[CH:7]=[CH:8][CH:9]=1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 867Malonic AcidHCID 765833-Bromobenzaldehyde

생성물 1

HCID 362513-(3-Bromophenyl)acrylic acid수율 94.4%

시약·촉매·용매 2

HCID 8082Piperidine촉매HCID 1049Pyridine용매

반응 조건

온도
100 °C

실험 절차

3-Bromobenzaldehyde (10.0 g, 54 mmol), malonic acid (10.1 g, 97 mmol) and piperidine (0.267 mL, 2.7 mmol) are treated with pyridine (30 mL) and heated at 100° C. for 3.5 h. The reaction mixture is cooled to room temperature, poured into 200 ml of 20% hydrochloric acid at 0° C.; the resultant precipitate is collected, washed with copious amounts of water and dried in a vacuum dessicator overnight to afford the title compound (11.64 g, 51 mmol).

후처리

  1. temperatureThe reaction mixture is cooled to room temperature
  2. customthe resultant precipitate is collected
  3. washwashed with copious amounts of water
  4. customdried in a vacuum dessicator overnight

출처 및 근거

ORD 기록
ord-d723d805d22049e68439ec36653ca220
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05731315

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