4-Toluenesulfonyl chloride → 5-Phenylpentyl p-toluenesulfonate

HRID 277896

반응식

HRID 277896 반응식
[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][OH:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.[C:20]1([CH3:30])[CH:25]=[CH:24][C:23]([S:26](Cl)(=[O:28])=[O:27])=[CH:22][CH:21]=1>C(Cl)Cl>[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][S:26]([C:23]2[CH:24]=[CH:25][C:20]([CH3:30])=[CH:21][CH:22]=2)(=[O:28])=[O:27])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 73974-Toluenesulfonyl chlorideHCID 8471TriethylamineHCID 615235-Phenyl-1-pentanol

생성물 1

HCID 152495035-Phenylpentyl p-toluenesulfonate수율 102.8%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 5-phenyl-1-pentanol (3.28 g, 20 mmoles) and triethylamine (6.13 ml, 44 mmoles) in CH2Cl2 (35 ml) under N2, p-toluen-sulphonyl chloride (4.19 g, 22 mmoles) was added and then put under stirring up to room temperature for 1 night. The mixture was washed with water, NaHCO3 and 5% HCl, anhydrified and brought to dryness to give 6.55 g of the title compound (yield: 100%).

후처리

  1. washThe mixture was washed with water, NaHCO3 and 5% HCl

출처 및 근거

ORD 기록
ord-02b648232c2e4188946f7fce31d6ec3d
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06358973B1

연결된 노트

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