Anisole → 4-Bromoanisole

HRID 27802

반응식

HRID 27802 반응식
[C:1]1([O:7][CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:9]Br>C(Cl)(Cl)Cl>[Br:9][C:4]1[CH:5]=[CH:6][C:1]([O:7][CH3:8])=[CH:2][CH:3]=1

참가 물질

4

반응물 2

HCID 7519AnisoleHCID 24408Bromine

생성물 1

HCID 77304-Bromoanisole수율 80%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

The bromination of anisole with one equivalent of bromine is chloroform, at room temperature, is reported to give an 80% yield of monobromoanisole. Grignard, Bellet and Courtot, Ann. Chim. 4, 28 (1915). The preparation of dibromoanisole from anisole, and of tribromoanisole from dibromoanisole, in carbon tetrachloride, is also reported. Kohn and Sussman, Monatsh. Chem. 46, 575 (1925). "Several days" reaction time is reported for the preparation of several tribromophenyl alkyl ethers. Yields are not reported. Baiford and Birosel, J. Am. Chem. Soc., 51, 1776 (1929). The bromination of anisole with three equivalents of bromine yields 1.5% tribromoanisole. Similarly, the bromination of monobromoanisole with two equivalents of bromine in chloroform is reported to give only small quantities of tribromoanisole, and tribromoanisole is reported not to brominate further. D. M. Birosel, Univ. Phillipines Natural Applied Sci. Bull. 1, 145 (1931).

후처리

  1. customat room temperature

출처 및 근거

ORD 기록
ord-b3cef7a29b304f9cb7de60fa5db6d751
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04223169

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