Glyoxylic Acid → 5,7-Di-tert-butyl-3-hydroxy-2-benzofuranone

HRID 278506

반응식

HRID 278506 반응식
[C:1]([C:5]1[CH:10]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:8]=[CH:7][C:6]=1[OH:15])([CH3:4])([CH3:3])[CH3:2].[C:16](O)(=[O:19])[CH:17]=[O:18].O.C1(C)C=CC(S(O)(=O)=O)=CC=1.O>ClCCCl>[C:11]([C:9]1[CH:10]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[C:6]2[O:15][C:17](=[O:18])[CH:16]([OH:19])[C:7]=2[CH:8]=1)([CH3:14])([CH3:13])[CH3:12]

참가 물질

6

반응물 4

HCID 760Glyoxylic AcidHCID 962WaterHCID 73112,4-Di-tert-butylphenolHCID 521998p-Toluenesulfonic acid monohydrate

생성물 1

HCID 68508215,7-Di-tert-butyl-3-hydroxy-2-benzofuranone

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

실험 절차

A mixture of 212.5 g (1.00 mol) of 2,4-di-tert-butylphenol (97%), 163.0 g (1.10 mol) of 50% aqueous glyoxylic acid and 0.5 g (2.6 mmol) of p-toluenesulfonic acid monohydrate in 300 ml of 1,2-dichloroethane is refluxed under nitrogen for 3.5 hours on a water separator. Afterwards the reaction mixture is concentrated on a vacuum rotary evaporator. The residue is taken up in 800 ml of hexane and washed three times with water. The aqueous phases are separated in the separating funnel and further extracted with 300 ml of hexane. The organic phases are combined, dried over magnesium sulfate and concentrated on a vacuum rotary evaporator. The residue yields 262.3 g (˜100%) of analytically pure 5,7-di-tert-butyl-3-hydroxy-3H-benzofuran-2-one in the form of a thick yellowish resin (compound (201), Table 2).

후처리

  1. concentrationAfterwards the reaction mixture is concentrated on a vacuum rotary evaporator
  2. washwashed three times with water
  3. customThe aqueous phases are separated in the separating funnel
  4. extractionfurther extracted with 300 ml of hexane
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated on a vacuum rotary evaporator

출처 및 근거

ORD 기록
ord-9a205a11fc60443ca9b1e7920677b20e
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06359148B1

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