Sodium Hydroxide → 5-(Pyridin-4-yl)thiophene-2-carboxylic acid

HRID 278555노트

반응식

HRID 278555 반응식
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[S:11][C:10]([C:12]([O:14]C)=[O:13])=[CH:9][CH:8]=2)=[CH:3][CH:2]=1.[OH-].[Na+]>C(O)C>[N:1]1[CH:2]=[CH:3][C:4]([C:7]2[S:11][C:10]([C:12]([OH:14])=[O:13])=[CH:9][CH:8]=2)=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 21928559Methyl 5-(pyridin-4-yl)thiophene-2-carboxylate

생성물 1

HCID 219285765-(Pyridin-4-yl)thiophene-2-carboxylic acid수율 94.6%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of the obtained methyl 5-(4-pyridyl)-2-thiophenecarboxylate (410 mg) in ethanol (20 ml) was added 1 N sodium hydroxide solution (4 ml) and the mixture was stirred at room temperature for 2 hours. The reaction solution was concentrated, and the residue was dissolved in water, to which was added 1 N hydrochloric acid (4 ml). The precipitate was filtered, washed with water and dried to give the title compound (363 mg).

후처리

  1. concentrationThe reaction solution was concentrated
  2. dissolutionthe residue was dissolved in water, to which
  3. additionwas added 1 N hydrochloric acid (4 ml)
  4. filtrationThe precipitate was filtered
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-b3bd37bc43a0402180e8c64f02ce3d2b
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06359134B1

반응 노트

불러오는 중…