Sodium Hydroxide → 2-(Pyridin-4-yl)-1,3-thiazole-4-carboxylic acid

HRID 278562노트

반응식

HRID 278562 반응식
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[S:8][CH:9]=[C:10]([C:12]([O:14]CC)=[O:13])[N:11]=2)=[CH:3][CH:2]=1.[OH-].[Na+]>C(O)C>[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[S:8][CH:9]=[C:10]([C:12]([OH:14])=[O:13])[N:11]=2)=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 595483Ethyl 2-(pyridin-4-YL)thiazole-4-carboxylate

생성물 1

HCID 7160912-(Pyridin-4-yl)-1,3-thiazole-4-carboxylic acid수율 95.7%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of the obtained ethyl 2-(4-pyridyl)-4-thiazolecarboxylate (1.5 g) in ethanol (10 ml) was added 1 N sodium hydroxide solution (10 ml), and the solution was stirred at room temperature for 2 hours. The reaction solution was concentrated and the residue was dissolved in water, to which was added 1 N hydrochloric acid (10 ml). The precipitate was filtered, washed with water and dried to give the title compound (1.264 g).

후처리

  1. concentrationThe reaction solution was concentrated
  2. dissolutionthe residue was dissolved in water, to which
  3. additionwas added 1 N hydrochloric acid (10 ml)
  4. filtrationThe precipitate was filtered
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-e1ede9ccf4ad448984aee4eacd500246
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06359134B1

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