Hydrochloric Acid → 3-Isopropoxy-4-nitrobenzoic acid

HRID 278839

반응식

HRID 278839 반응식
[N+:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8]([O-:10])=[O:9])=[C:6](CC)[C:5]=1[O:15][CH:16]([CH3:18])[CH3:17])([O-:3])=[O:2].[OH-].[K+].Cl>C(O)C.O>[N+:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][C:5]=1[O:15][CH:16]([CH3:18])[CH3:17])([O-:3])=[O:2]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 178301674-Nitro-3-isopropoxy-ethylbenzoate

생성물 1

HCID 6029283-Isopropoxy-4-nitrobenzoic acid수율 88.3%

시약·촉매·용매 2

HCID 702Ethanol용매2회HCID 962Water용매

실험 절차

To a solution of 4-nitro-3-isopropoxy-ethylbenzoate (11.85 g, 0.047 mol) in ethanol (200 mL) was added a solution of potassium hydroxide (2.6 g, 0.047 mol) in water (5 mL). The reaction mixture was heated to reflux for 2 hours. The ethanol volume was reduced to 100 mL and the mixture then poured into 1 N HCl (100 mL). The crystals that precipitated, were filtered off and dried in a vacuum oven to yield 9.35 g (88%) of 4-nitro-3-isopropoxybenzoic acid. MS ES− 225, ES+ 223.

후처리

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 2 hours
  3. customThe crystals that precipitated
  4. filtrationwere filtered off
  5. customdried in a vacuum oven

출처 및 근거

ORD 기록
ord-8af2072f27904393ab9fccf4bbb71581
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06361931B1

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