Caffeic Acid → HCID 9910538, 화합물

HRID 278849

반응식

HRID 278849 반응식
C(O[C:9]([NH:11][C@H:12]([C:21]([NH:23][CH2:24][CH2:25][C:26]1[CH:33]=[CH:32][C:30]([OH:31])=[C:28]([OH:29])[CH:27]=1)=[O:22])[CH2:13][C:14](=[O:20])[O:15]C(C)(C)C)=[O:10])C1C=CC=CC=1.C(O)(=O)/[CH:35]=[CH:36]/[C:37]1[CH:44]=[CH:43][C:41]([OH:42])=[C:39]([OH:40])[CH:38]=1>>[C:9]([NH:11][C@H:12]([C:21]([NH:23][CH2:24][CH2:25][C:26]1[CH:33]=[CH:32][C:30]([OH:31])=[C:28]([OH:29])[CH:27]=1)=[O:22])[CH2:13][C:14](=[O:20])[OH:15])(=[O:10])/[CH:35]=[CH:36]/[C:37]1[CH:44]=[CH:43][C:41]([OH:42])=[C:39]([OH:40])[CH:38]=1

참가 물질

3

반응물 2

HCID 689043Caffeic AcidHCID 131723152HCID 131723152, 화합물

생성물 1

HCID 9910538HCID 9910538, 화합물수율 52.4%

실험 절차

N-(N′-benzyloxycarbonyl-Oγ-tert-butyl-L-aspartyl)dopamine (1.0 g, 2.3 mmol) was deprotected by hydrogenolysis as described in example 5. The product thus obtained was then coupled with caffeic acid (621 mg, 3.5 mmol) according to the indications of example 4. Purification by flash chromatography using 30-50% AcOEt/CH2Cl2 containing 1% AcOH yielded 519 mg (47%) of the title compound as yellow crystals.

후처리

  1. customThe product thus obtained
  2. customPurification by flash chromatography

출처 및 근거

ORD 기록
ord-255f868c04ff4cfaadfd676d1d709f94
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06362165B1

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