Ethanol → 3-Chloro-6-(3,5-dimethyl-4-amino-1-pyrazolyl)-pyridazine
반응식
[Cl:1][C:2]1[N:3]=[N:4][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([N:14]3C(=O)C4=CC=CC=C4C3=O)[C:10]([CH3:25])=[N:9]2)=[CH:6][CH:7]=1.C(O)C.O.NN>O>[Cl:1][C:2]1[N:3]=[N:4][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([NH2:14])[C:10]([CH3:25])=[N:9]2)=[CH:6][CH:7]=1참가 물질
5
실험 절차
A mixture of 3.54 g (0.01 moles) of 3-chloro-6-(3,5-dimethyl-4-phthalimido-1-pyrazolyl)-pyridazine, 40 ml of ethanol and 1.08 g (0.01 moles) of 98% hydrazine hydrate is heated to reflux for 3 hours and the mixture is poured into 100 ml of water. After cooling the precipitated crystals are filtered, washed with water, triturated with 10 ml of hot ethanol, filtered and dried. Yield: 1.8 g (81%); m.p. 165°-168° C.
후처리
- temperatureis heated
- temperatureto reflux for 3 hours
- temperatureAfter cooling the precipitated crystals
- filtrationare filtered
- washwashed with water
- customtriturated with 10 ml of hot ethanol
- filtrationfiltered
- customdried
출처 및 근거
- ORD 기록
- ord-2de05f19ff944bc5b5923558451fcc83
- 출처 데이터셋
- uspto-grants-1980_09
- 특허 번호
- US04224325
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