Hydrazine hydrate (1:1) → 3(2H)-Pyridazinone, 6-(3,5-dimethyl-1H-pyrazol-1-yl)-, hydrazone

HRID 27895

반응식

HRID 27895 반응식
Cl[C:2]1[N:3]=[N:4][C:5]([N:8]2[C:12]([CH3:13])=[CH:11][C:10]([CH3:14])=[N:9]2)=[CH:6][CH:7]=1.O.[NH2:16][NH2:17].O1CCOCC1>O>[NH:16]([C:2]1[N:3]=[N:4][C:5]([N:8]2[C:12]([CH3:13])=[CH:11][C:10]([CH3:14])=[N:9]2)=[CH:6][CH:7]=1)[NH2:17]

참가 물질

5

반응물 3

HCID 24654Hydrazine hydrate (1:1)HCID 312751,4-DioxaneHCID 3210733-Chloro-6-(3,5-dimethylpyrazol-1-yl)pyridazine

생성물 1

HCID 30539723(2H)-Pyridazinone, 6-(3,5-dimethyl-1H-pyrazol-1-yl)-, hydrazone

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 34.2 g. of 3-chloro-6-(3,5-dimethyl-1-pyrazolyl)-pyridazine, 100 ml of 72% hydrazine hydrate and 200 ml of dioxane is stirred at 90°-95° C. for 14 hours, then the mixture is poured into 1 liter of water, extracted three times with 150 ml of chloroform each, and the combined organic phases are dried over magnesium sulphate. After evaporation of the solvent, the residue is recrystallized from isopropanol. Yield: 27 g /80%/; m.p.: 142°-143° C.

후처리

  1. additionA mixture of 34.2 g
  2. extractionextracted three times with 150 ml of chloroform each, and the combined organic phases
  3. dry with materialare dried over magnesium sulphate
  4. customAfter evaporation of the solvent
  5. customthe residue is recrystallized from isopropanol

출처 및 근거

ORD 기록
ord-4ac82b5535e94a9f90c855027f1f8454
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04224325

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