Hydrochloric Acid → 3,5-Dichloro-2-isothiocyanatopyridine

HRID 27901

반응식

HRID 27901 반응식
[Cl:1][C:2]1[C:3]([NH2:9])=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1.Cl.[N-]=[C:12]=[S:13]>>[Cl:1][C:2]1[C:3]([N:9]=[C:12]=[S:13])=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 778863,5-Dichloro-3-pyridylamineHCID 178418790HCID 178418790, 화합물

생성물 1

HCID 233404453,5-Dichloro-2-isothiocyanatopyridine

실험 절차

3,5-Dichloro-2-amino pyridine (8.15, 0.05 mol) was treated with thiophosgenes (10% soln. in toluene, 55 ml). The mixture was refluxed until clear solution was obtained and no further hydrochloric acid gas was being evolved. The mixture was cooled, and the solid which crystallised was removed by filtration. The mother liquors, after evaporation and crystallisation of the residual oil, yielded 5.5 g. (55%) of the required isothiocyanate as pale yellow needles m. pt. 45°-6°.

후처리

  1. temperatureThe mixture was refluxed until clear solution
  2. customwas obtained
  3. temperatureThe mixture was cooled
  4. customthe solid which crystallised
  5. customwas removed by filtration
  6. customThe mother liquors, after evaporation and crystallisation of the residual oil
  7. customyielded 5.5 g

출처 및 근거

ORD 기록
ord-dffacfefda164193be659bca22101673
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04224331

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