Dimethylformamide → 4-Bromo-2,2-diphenylbutyric chloride

HRID 279073

반응식

HRID 279073 반응식
[Br:1][CH2:2][CH2:3][C:4]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:5](O)=[O:6].S(Cl)([Cl:22])=O.CN(C)C=O>C(Cl)(Cl)Cl>[Br:1][CH2:2][CH2:3][C:4]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:5]([Cl:22])=[O:6]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 27569594-Bromo-2,2-diphenylbutyric acid

생성물 1

HCID 222500664-Bromo-2,2-diphenylbutyric chloride수율 94.7%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

4-Bromo-2,2-diphenylbutyric acid 23 g (72 mmol) was suspended in 150 mL of chloroform. At room temperature, 20 mL (270 mmol) of thionyl chloride was added dropwise to the resulting suspension. After addition of 0.2 mL of dimethylformamide, the resulting mixture was heated under reflux for 4 hours. After completion of the reaction, the solvent was concentrated under reduced pressure, whereby 23 g (yield: 94.7%) of 4-bromo-2,2-diphenylbutyric chloride was obtained.

후처리

  1. temperaturethe resulting mixture was heated
  2. temperatureunder reflux for 4 hours
  3. customAfter completion of the reaction
  4. concentrationthe solvent was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-18aefa498618404db98a73d8d2df4637
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06362203B1

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