Dimethylformamide → 3-Phenoxybenzyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoate

HRID 27931

반응식

HRID 27931 반응식
CN(C=O)C.[Cl:6][C:7]1[CH:8]=[CH:9][C:10]2[S:14][C:13]([CH:15]([CH:19]([CH3:21])[CH3:20])[C:16]([OH:18])=[O:17])=[CH:12][C:11]=2[CH:22]=1.C([O-])([O-])=O.[K+].[K+].[O:29]([C:36]1[CH:37]=[C:38]([CH:41]=[CH:42][CH:43]=1)[CH2:39]Br)[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>CCOCC>[Cl:6][C:7]1[CH:8]=[CH:9][C:10]2[S:14][C:13]([CH:15]([CH:19]([CH3:20])[CH3:21])[C:16]([O:18][CH2:39][C:38]3[CH:41]=[CH:42][CH:43]=[C:36]([O:29][C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)[CH:37]=3)=[O:17])=[CH:12][C:11]=2[CH:22]=1

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 945441-(Bromomethyl)-3-phenoxybenzeneHCID 542046732-(5-Chloro-2-benzothienyl)-3-methylbutanoic acid

생성물 1

HCID 544776893-Phenoxybenzyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoate

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A mixture of 20 ml DMF, 2-(5-chloro-2-benzothienyl)-3-methylbutanoic acid (0.5 g), K2CO3 (0.51 g) and 3-phenoxybenzyl bromide (0.44 g) is stirred, under nitrogen, for about 15 hours. The mixture is then taken up in ether, washed with water and brine, dried over Na2SO4 and solvent removed. The crude product is plated developing with 10% ether/hexane to give 3-phenoxybenzyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoate.

후처리

  1. washwashed with water and brine
  2. dry with materialdried over Na2SO4 and solvent
  3. customremoved

출처 및 근거

ORD 기록
ord-afd7ba97cc11477984f0728908ef7c09
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04224330

연결된 노트

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