Pyridine → N-Methoxy-N,4-dimethyloxazole-5-carboxamide

HRID 2794

반응식

HRID 2794 반응식
[CH3:1][C:2]1[N:3]=[CH:4][O:5][C:6]=1[C:7](Cl)=[O:8].Cl.[CH3:11][NH:12][O:13][CH3:14].N1C=CC=CC=1.C(=O)([O-])O.[Na+]>C(Cl)(Cl)Cl>[CH3:14][O:13][N:12]([CH3:11])[C:7]([C:6]1[O:5][CH:4]=[N:3][C:2]=1[CH3:1])=[O:8]

참가 물질

6

반응물 4

HCID 1049PyridineHCID 81138Methanamine, N-methoxy-, hydrochloride (1:1)HCID 516892Sodium BicarbonateHCID 27952174-Methyloxazole-5-carbonyl chloride

생성물 1

HCID 18925369N-Methoxy-N,4-dimethyloxazole-5-carboxamide

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

4-Methyl-5-oxazolecarbonyl chloride (15 g) and N,O-dimethylhydroxylamine hydrochloride (11 g) in dry chloroform (100 ml) were cooled to 0° C. and dry pyridine (28.5 g) was added. The mixture was allowed to warm to room temperature. After 30 minutes aqueous sodium hydrogen carbonate was added and the organic layer separated. The aqueous layer was extracted with dichloromethane. The combined organic layers were washed, dried and evaporated. The residue was purified by flash chromatography to yield the title compound as a white solid. M.p. 59°-60° C.

후처리

  1. customthe organic layer separated
  2. extractionThe aqueous layer was extracted with dichloromethane
  3. washThe combined organic layers were washed
  4. customdried
  5. customevaporated
  6. customThe residue was purified by flash chromatography

출처 및 근거

ORD 기록
ord-b9c8478b753b4132a133ace38f7e208b
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05731335

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